Late neurologic complication after deep hypothermia and circulatory arrest—A hypothesis

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Neurologic Injury Associated with Rewarming from Hypothermia: Is Mild Hypothermia on Bypass Better than Deep Hypothermic Circulatory Arrest?

Many known risk factors for adverse cardiovascular and neurological outcomes in children with congenital heart defects (CHD) are not modifiable; however, the temperature and blood flow during cardiopulmonary bypass (CPB), are two risk factors, which may be altered in an attempt to improve long-term neurological outcomes. Deep hypothermic circulatory arrest, traditionally used for aortic arch re...

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Bleeding following deep hypothermia and circulatory arrest in children.

Deep hypothermic circulatory arrest (DHCA) is a technique of extracorporeal circulation commonly used in children with complex congenital heart defects undergoing surgical repairs. The use of profound cooling (20 degrees C) and complete cessation of circulation allow adequate exposure and correction of these complex lesions, with enhanced cerebral protection. However, the profound physiologic s...

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Biochemical changes during circulatory arrest under deep hypothermia.

At body temperatures between 100 C. and 150 C. complete circulatory arrest is relatively safe for periods of 60 minutes or more, giving time for extensive open heart operations. The clinical use of this procedure has far outstripped its full investigation under controlled conditions. The time limit for arrest at any given temperature is not known, nor are the types of damage which will occur at...

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Pyrexia and neurologic outcomes after therapeutic hypothermia for cardiac arrest.

OBJECTIVE Therapeutic hypothermia, also known as targeted temperature management (TTM), improves clinical outcomes in patients resuscitated from cardiac arrest. Hyperthermia after discontinuation of active temperature management ("rebound pyrexia") has been observed, but its incidence and association with clinical outcomes is poorly described. We hypothesized that rebound pyrexia is common afte...

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Predictors of neurologic outcome in hypothermia after cardiac arrest.

OBJECTIVE To evaluate the predictive value of neurologic prognostic indicators for patients treated with hypothermia after surviving cardiopulmonary arrest. METHODS Patients who survived cardiopulmonary arrest were prospectively collected from June 2006 to October 2009. Detailed neurologic examinations were performed. Serum neuron specific enolase (NSE) measurements, brain imaging findings, s...

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ژورنال

عنوان ژورنال: The Journal of Thoracic and Cardiovascular Surgery

سال: 1992

ISSN: 0022-5223

DOI: 10.1016/s0022-5223(19)35086-x